As of 7 p.m. Friday, the National Weather Service's office in Weldon Spring, Missouri, reported about 5 inches of snow.
The Missouri Department of Transportation warned residents not to travel in the storm if it wasn't necessary.
The University of Missouri men's basketball game at the University of SC was also canceled Saturday because of weather-related travel problems, the team tweeted.
Missouri isn't the only state being hit by this traveling snow storm. The National Weather Center said 17 inches of snow has fallen in central Missouri.
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A major winter storm is wreaking havoc on millions of Americans this weekend as it carves its way across the Midwest toward the Atlantic.
The storm moved into Kansas and Nebraska from the Rockies on Friday, then east into Missouri and IL, covering roads and making driving unsafe.
In Illinois, the weather service snow would begin in southwestern Illinois and spread northeast throughout the evening, reaching the Chicago area by Saturday morning. In St. Louis on Friday night, parts of I-44, I-55, I-64 and I-70 were partially closed because of current snowfall, and more is on the way.
The latest amounts of snowfall saw Cook, Nebraska experience 11.8 inches, Bridgetown, Illinois 10.5 inches and Amy and Scott State Lake in Kansas nine inches. Motorists found themselves stranded as snow-covered roads became impossible to pass.
Half a foot of snow also is expected to fall across southern Illinois, Indiana and into Virginia.
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25 cm are in the forecast for Washington, D.C., which finds itself in the storm's sights for Sunday.
The Appalachians will pick up ice and snow in the mountains of Virginia and North Carolina, forecasters said. Four to 6 inches are predicted for Washington and 2 to 3 inches for Baltimore, they said. The southern mountains of North Carolina near SC and Georgia will likely see more rain than sleet and snow.
AccuWeather meteorologist Bill Deger said in a blog post: "In much of swath from Missouri to southern OH, this will heavy and wet and a strain to shovel".
There is a small chance the southern Appalachians will get enough freezing rain and sleet to turn into an ice event Saturday into Sunday.
The Southeast has seen abundant precipitation in December and January, and the additional rain could put a strain on rivers already high.
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