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Murray scored his eighth goal of the season with a penalty in Brighton's 3-1 victory over Crystal Palace on Tuesday but the 35-year-old sustained the injury in a fall and was substituted in the first half.
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Murray had to be replaced by Andone and, after a brilliant goal-line clearance from Bernardo kept Milivojevic out, the Romanian punished Palace on the counter-attack in the fourth minute of stoppage time. Hughton decided not to start leading scoring Glenn Murray and Alireza Jahanbakhsh against Huddersfield.
It was the second successive appearance in which the Belgian had scored, and Hughton is pleased with his focus as Brighton target a third straight Premier League win.
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It is questionable whether Palace will contribute to the tally unless Zaha rediscovers his goalscoring touch, although it is worth noting that they have conceded at least two goals in eight of the 10 matches where they have failed to keep a clean sheet.
Brighton have now won six Premier League games this term and are placed 10th with 21 points in the EPL log.
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Replays appeared to show the Palace man had touched the ball before the Colombian went down, but Glenn Murray converted the spot kick for his ninth league goal of the season. They travel to Burnley for their next game on Saturday. Brighton will take on Burnley at Turf Moor on the same day.