Goalkeeper Lloris sustained a thigh problem during last month's 3-0 win at Manchester United, which meant he missed the subsequent 2-1 loss at Watford and France's worldwide commitments over the past week.
Tottenham will also be without Dele Alli after he picked up a hamstring injury on global duty.
Pochettino confirmed that Lloris would remain captain despite his drunk-driving case, replying "of course" when asked whether that would be the situation.
The World Cup victor was stopped in his Porsche Panamera by police in the early hours of August 24 and provided a sample containing 80 micrograms of alcohol per 100 millilitres of breath, more than twice the legal limit in England and Wales.
Liverpool winger Shaqiri: Klopp always demanding more
This is an idea that was specifically brought up at an Irish news and wagering site that prognosticates on the latest in sports . The Reds face Tottenham at Wembley on Saturday following the conclusion of the global break.
Manager Pochettino said: 'I think of course he is the first to regret about everything. All that happened (in court) is not good and he does not feel great.
"I think we are always confident that we can beat any team but of course the game on Saturday will be completely different (to last year), a different season", Pochettino, whose side have nine points from four games, said.
'It was a mistake & then we are men & women - we can all make mistakes.
Lloris missed the defeat at Watford before the global break after suffering the problem during the win over Manchester United in late August and the French worldwide is expected to be out for several weeks. "That is a massive lesson for everyone, he was the first to tell me he made a mistake".
Russian Bear Bombers Near Alaska Intercepted Again
Such intercepts have happened about 60 times between 2007 and 2017, The New York Times reported a year ago . However, during that earlier intercept, the Russian Tu-95s were not escorted by Russian fighter jets.
"He already knew in the moment that it was a big mistake. Now, because he is clever, he learns and he is going to move on".
"If not, we're not going to take a risk because he missed a lot of games and we have ahead of lot of games to play".
Aung San Suu Kyi: Rohingya crisis 'could have been handled better'
Although Suu Kyi lacks command control over the armed forces, she has been criticized for not doing more to stop the carnage. Sean Bain, of the International Commission of Jurists, said: "Open courts are created to shed light on the justice process".