Because it was all a novel study, the team only focused on the early stages of the lung development following the transplants, so the pigs had to be euthanized in order for the researchers to see how the lungs had developed within the bodies. Researchers are considering the possibilities of using donor lungs, or a 3D print of a "scaffolding" to work from when it comes to producing similar results in humans. Bioengineered organs are a hopeful solution to this problem, enabling needed organs to be engineered in a lab, then transplanted into the patient. Lungs that were not considered suitable previously can still be used in this process to create a healthy DNA-matched lung for the organ recipient.
They then created a cocktail of nutrients and lung cells from the pig which was to receive the transplant, and placed it in a tank with the organ skeleton.
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The next step of the research is to test whether the newly grown lung works by basically blocking the function of the pig's primary lung and seeing if they can still get oxygen into their blood and to the tissues.
"In these studies, we talk about producing human lungs using human scaffolds", Dr Nichols explained.
Six bioengineered lungs were created in total, though only four of the animals received them, due to surgical issues.
There was no signs of pulmonary edema, which is usually a sign of the vasculature not being mature enough, according to the researchers. "The bioengineered lungs continued to develop post-transplant without any infusions of growth factors, the body provided all of the building blocks that the new lungs needed".
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He also reiterated that police believe Paddock acted alone and said that they do not anticipate charging anyone else. They have illustrated the chaos, heartbreak and heroism from police, first-responders, concert-goers and more.
"Bioengineered lungs can be made at any time so an individual does not have to wait until an organ is available for them".
For this reason, future studies will look at long-term survival and maturation of the tissues as well as gas exchange capability. Even so, the research group believes it could grow human-ready lungs in the next five to 10 years.
Given that some organs can not be transplanted from a living person to another (such as the heart), this narrows down the availability options even more, which is one of the reasons why the black market on organs is thriving.
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