Hormone Levels Likely Influence A Woman's Risk Of Alzheimer's. But Exactly How?

More than senior moments better dementia detection is urged

Women's Alzheimer's test needed as superior verbal skills mask onset of the disease

In fact, going through menopause at age 45 or younger seemed to increase a woman's risk of developing the disease by as much as 28 percent.

The researchers found that women in the study with three or more children had a 12 percent lower risk of dementia compared to women with one child. Earlier studies conducted in large number of women has shown that HRT containing estrogen and progesterone can raise the risk of stroke, blood clots, breast cancer and dementia among the women.

"More women than men have Alzheimer's disease or other dementias; nearly two-thirds of Americans with Alzheimer's are women", said Maria Carrillo, PhD, Alzheimer's Association Chief Science Officer.

Suven has excellent portfolio of new molecules through 4 mechanisms of action using 5-HT6, 5-HT4, H3 receptors and M1PAM for the symptomatic treatment of cognitive impairment in Alzheimer's disease but also possibly useful in reducing the disease progression. They emerged from the first study to explore women's lifetime dementia prospects by tracking a very large group of women over a long period - for some, as long as 53 years. And it found an association between a woman's reproductive history and her risk of memory problems later in life. But now, researchers have homed in on this link to hormones like estrogen and progesterone as a possible explanation. From 1964 to 1973, the undertaking enrolled female members of Kaiser Permanente ages 40 to 55.

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One of the studies presented at the conference has noted that more number of births in a woman is associated with a lower risk of dementia. The Women's Health Initiative after their initial discouraging results on HRT came up with new interpretations after a decade saying that they had initially included only elderly women.

In addition, with each additional pregnancy miscarriage a woman reported, her average risk of dementia rose by 8percent.

"Possible causes of dementia in women, in particular reproductive factors, are not well understood", said Gilsanz. Additionally, women who indicated having their first menstrual period at age 16 or older were at 31 percent greater risk than those who reported having their first menstrual period at 13. This has changed over the years they note.

If immune overreaction is a feature of dementias such as Alzheimer's disease (and there is strong evidence that it is), then there might be some protective value to getting the immune system to "stand down" during early pregnancy, Fox added.

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Other research presented Monday expands the picture of women's dementia risk in ways that offer other insights.

An Alzheimer's test specifically for women should be developed after a new study found superior female verbal skills disguise the onset of the disease, scientists have said. The results also showed that women who were fertile between ages of 21 and 30 years had a 33 percent higher risk of dementia compared to women who were fertile for a longer period.

A need for sex-based standards for cognitive assessments, to improve early detection in women.

No medication has been found effective in altering the course of Alzheimer's disease. That has put a premium on early identification of those at risk.

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